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USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database


USC-OGP 2-DE database 
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Searching in 'USC-OGP 2-DE database' for entry matching: P04792




USC-OGP 2-DE database:  P04792


P04792


General information about the entry
View entry in simple text format
Entry nameHSPB1_HUMAN
Primary accession numberP04792
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Heat shock protein beta-1; Short=HspB1; AltName: Full=28 kDa heat shock protein; AltName: Full=Estrogen-regulated 24 kDa protein; AltName: Full=Heat shock 27 kDa protein; Short=HSP 27; AltName: Full=Stress-responsive protein 27; Short=SRP27;.
Gene nameName=HSPB1
Synonyms=HSP27, HSP28
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

PLATELET_4-7 {PLATELET 4-7}
Homo sapiens (Human)
PLATELET_4-7
  map experimental info
 
PLATELET_4-7

MAP LOCATIONS:
pI=5.24; Mw=26707
pI=5.34; Mw=26520
pI=5.41; Mw=26520
pI=5.83; Mw=26335
pI=6.06; Mw=23783



PLATELET_5-6 {PLATELET 5-6}
Homo sapiens (Human)
PLATELET_5-6
  map experimental info
 
PLATELET_5-6

MAP LOCATIONS:
pI=5.19; Mw=30153
pI=5.57; Mw=29807
pI=5.77; Mw=29597
pI=5.81; Mw=28870
pI=5.83; Mw=27642
pI=5.45; Mw=26963



PLATELET_6-11 {PLATELET 6-11}
Homo sapiens (Human)
PLATELET_6-11
  map experimental info
 
PLATELET_6-11

MAP LOCATIONS:
pI=5.69; Mw=25920



UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10}
Homo sapiens (Human)
UVEAL_MELANOMA_3-10
  map experimental info
 
UVEAL_MELANOMA_3-10

MAP LOCATIONS:
pI=4.42; Mw=32219
pI=5.84; Mw=28952
pI=5.29; Mw=28871
pI=5.83; Mw=27756
pI=6.07; Mw=27522
pI=5.05; Mw=27445
pI=5.55; Mw=27445
pI=5.13; Mw=26515
pI=5.35; Mw=25790
pI=6.01; Mw=25688
pI=6.52; Mw=25485
pI=6.61; Mw=24887
pI=6.93; Mw=22446
pI=5.67; Mw=18705

Cross-references
UniProtKB/Swiss-ProtP04792; HSPB1_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry nameHSPB1_HUMAN
Primary accession numberP04792
Secondary accession number(s) B2R4N8 Q6FI47 Q96C20 Q96EI7 Q9UC31 Q9UC34 Q9UC35 Q9UC36
Sequence was last modified on September 26, 2001 (version 2)
Annotations were last modified on March 15, 2017 (version 208)
Name and origin of the protein
DescriptionRecName: Full=Heat shock protein beta-1; Short=HspB1; AltName: Full=28 kDa heat shock protein; AltName: Full=Estrogen-regulated 24 kDa protein; AltName: Full=Heat shock 27 kDa protein; Short=HSP 27; AltName: Full=Stress-responsive protein 27; Short=SRP27;
Gene nameName=HSPB1
Synonyms=HSP27, HSP28
Encoded onName=HSPB1; Synonyms=HSP27, HSP28
Keywords3D-structure; Acetylation; Chaperone; Charcot-Marie-Tooth disease; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Methylation; Neurodegeneration; Neuropathy; Nucleus; Phosphoprotein; Reference proteome; Stress response.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLL39370; AAA62175.1; ALT_FRAME; Genomic_DNA
EMBLX54079; CAA38016.1; -; mRNA
EMBLZ23090; CAA80636.1; -; mRNA
EMBLAB020027; BAB17232.1; -; mRNA
EMBLU90906; AAB51056.1; -; mRNA
EMBLCR407614; CAG28542.1; -; mRNA
EMBLCR536489; CAG38728.1; -; mRNA
EMBLBT019888; AAV38691.1; -; mRNA
EMBLAK311894; BAG34835.1; -; mRNA
EMBLDQ379985; ABC88475.1; -; Genomic_DNA
EMBLAC006388; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLCH471220; EAW71803.1; -; Genomic_DNA
EMBLBC000510; AAH00510.1; -; mRNA
EMBLBC012292; AAH12292.1; -; mRNA
EMBLBC012768; AAH12768.1; -; mRNA
EMBLBC014920; AAH14920.1; -; mRNA
EMBLBC073768; AAH73768.1; -; mRNA
EMBLX16477; CAA34498.1; ALT_FRAME; mRNA
EMBLS74571; AAB20722.1; ALT_FRAME; mRNA
CCDSCCDS5583.1; -; .
PIRS12102; HHHU27; .
RefSeqNP_001531.1; NM_001540.3; .
UniGeneHs.520973; -; .
PDB2N3J; NMR; -; A/B=80-176
PDB3Q9P; X-ray; 2.00 A; A=90-171
PDB3Q9Q; X-ray; 2.20 A; A/B=90-171
PDB4MJH; X-ray; 2.60 A; A/C=84-176
B/D=179-186PDBsum; 2N3J; -; .
PDBsum3Q9P; -; .
PDBsum3Q9Q; -; .
PDBsum4MJH; -; .
ProteinModelPortalP04792; -; .
SMRP04792; -; .
BioGrid109547; 400; .
DIPDIP-412N; -; .
IntActP04792; 307; .
MINTMINT-1368692; -; .
STRING9606.ENSP00000248553; -; .
BindingDBP04792; -; .
ChEMBLCHEMBL5976; -; .
DrugBankDB06094; OGX-427; .
iPTMnetP04792; -; .
PhosphoSitePlusP04792; -; .
SwissPalmP04792; -; .
BioMutaHSPB1; -; .
DMDM19855073; -; .
DOSAC-COBS-2DPAGEP04792; -; .
OGPP04792; -; .
REPRODUCTION-2DPAGEIPI00025512; -; .
REPRODUCTION-2DPAGEP04792; -; .
SWISS-2DPAGEP04792; -; .
UCD-2DPAGEP04792; -; .
EPDP04792; -; .
PaxDbP04792; -; .
PeptideAtlasP04792; -; .
PRIDEP04792; -; .
TopDownProteomicsP04792; -; .
DNASU3315; -; .
EnsemblENST00000248553; ENSP00000248553; ENSG00000106211; .
GeneID3315; -; .
KEGGhsa:3315; -; .
CTD3315; -; .
DisGeNET3315; -; .
GeneCardsHSPB1; -; .
GeneReviewsHSPB1; -; .
HGNCHGNC:5246; HSPB1; .
HPACAB004439; -; .
HPACAB047330; -; .
HPACAB047331; -; .
HPACAB047332; -; .
HPAHPA000497; -; .
MalaCardsHSPB1; -; .
MIM602195; gene; .
MIM606595; phenotype; .
MIM608634; phenotype; .
neXtProtNX_P04792; -; .
OpenTargetsENSG00000106211; -; .
Orphanet99940; Autosomal dominant Charcot-Marie-Tooth disease type 2F; .
Orphanet139525; Distal hereditary motor neuropathy type 2; .
PharmGKBPA29511; -; .
eggNOGKOG3591; Eukaryota; .
eggNOGENOG410YERS; LUCA; .
GeneTreeENSGT00760000119238; -; .
HOVERGENHBG054766; -; .
InParanoidP04792; -; .
KOK04455; -; .
OMADQSFGMP; -; .
OrthoDBEOG091G0USC; -; .
PhylomeDBP04792; -; .
TreeFamTF105049; -; .
ReactomeR-HSA-4420097; VEGFA-VEGFR2 Pathway; .
ReactomeR-HSA-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA; .
ReactomeR-HSA-5687128; MAPK6/MAPK4 signaling; .
SIGNORP04792; -; .
ChiTaRSHSPB1; human; .
GeneWikiHsp27; -; .
GenomeRNAi3315; -; .
PROPR:P04792; -; .
ProteomesUP000005640; Chromosome 7; .
BgeeENSG00000106211; -; .
CleanExHS_HSPB1; -; .
ExpressionAtlasP04792; baseline and differential; .
GenevisibleP04792; HS; .
GOGO:1904115; C:axon cytoplasm; IEA:GOC; .
GOGO:0005737; C:cytoplasm; IDA:UniProtKB; .
GOGO:0005856; C:cytoskeleton; TAS:UniProtKB; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0070062; C:extracellular exosome; IDA:UniProtKB; .
GOGO:0031012; C:extracellular matrix; IDA:BHF-UCL; .
GOGO:0005615; C:extracellular space; IDA:UniProtKB; .
GOGO:0005925; C:focal adhesion; IDA:UniProtKB; .
GOGO:0005634; C:nucleus; IDA:UniProtKB; .
GOGO:0005886; C:plasma membrane; IEA:Ensembl; .
GOGO:0000502; C:proteasome complex; ISS:BHF-UCL; .
GOGO:0005819; C:spindle; IEA:UniProtKB-SubCell; .
GOGO:0030018; C:Z disc; IEA:Ensembl; .
GOGO:0042802; F:identical protein binding; IMP:UniProtKB; .
GOGO:0044183; F:protein binding involved in protein folding; IMP:UniProtKB; .
GOGO:0019901; F:protein kinase binding; IPI:UniProtKB; .
GOGO:0005080; F:protein kinase C binding; ISS:BHF-UCL; .
GOGO:0008426; F:protein kinase C inhibitor activity; ISS:BHF-UCL; .
GOGO:0003723; F:RNA binding; IDA:UniProtKB; .
GOGO:0043130; F:ubiquitin binding; ISS:BHF-UCL; .
GOGO:0099641; P:anterograde axonal protein transport; IMP:UniProtKB; .
GOGO:0035924; P:cellular response to vascular endothelial growth factor stimulus; IMP:BHF-UCL; .
GOGO:0061077; P:chaperone-mediated protein folding; IMP:UniProtKB; .
GOGO:0035556; P:intracellular signal transduction; IMP:BHF-UCL; .
GOGO:0006928; P:movement of cell or subcellular component; TAS:UniProtKB; .
GOGO:0043066; P:negative regulation of apoptotic process; TAS:UniProtKB; .
GOGO:1902176; P:negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; ISS:BHF-UCL; .
GOGO:0006469; P:negative regulation of protein kinase activity; ISS:BHF-UCL; .
GOGO:0070527; P:platelet aggregation; IMP:UniProtKB; .
GOGO:0045766; P:positive regulation of angiogenesis; IMP:BHF-UCL; .
GOGO:0043536; P:positive regulation of blood vessel endothelial cell migration; IMP:BHF-UCL; .
GOGO:2001028; P:positive regulation of endothelial cell chemotaxis; IMP:BHF-UCL; .
GOGO:0038033; P:positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; IMP:BHF-UCL; .
GOGO:0032731; P:positive regulation of interleukin-1 beta production; ISS:BHF-UCL; .
GOGO:0042535; P:positive regulation of tumor necrosis factor biosynthetic process; ISS:BHF-UCL; .
GOGO:0010506; P:regulation of autophagy; NAS:ParkinsonsUK-UCL; .
GOGO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; ISS:BHF-UCL; .
GOGO:0043488; P:regulation of mRNA stability; TAS:Reactome; .
GOGO:0001932; P:regulation of protein phosphorylation; IMP:UniProtKB; .
GOGO:0006446; P:regulation of translational initiation; TAS:ProtInc; .
GOGO:0006986; P:response to unfolded protein; NAS:UniProtKB; .
GOGO:0009615; P:response to virus; IEP:UniProtKB; .
GOGO:0001895; P:retina homeostasis; IEP:UniProtKB; .
GOGO:0048010; P:vascular endothelial growth factor receptor signaling pathway; TAS:Reactome; .
Gene3D2.60.40.790; -; 2; .
InterProIPR002068; A-crystallin/Hsp20_dom; .
InterProIPR001436; Alpha-crystallin/HSP; .
InterProIPR031107; HSP20; .
InterProIPR008978; HSP20-like_chaperone; .
PANTHERPTHR11527; PTHR11527; 1; .
PfamPF00011; HSP20; 1; .
PRINTSPR00299; ACRYSTALLIN; .
SUPFAMSSF49764; SSF49764; 1; .
PROSITEPS01031; HSP20; 1; .



USC-OGP 2-DE database image


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Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

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